Cheap Flights from Cancun to Panama City Starting at $146

A direct flight is the most convenient and comfortable way to fly from Cancun to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.

Flights from Cancun to Panama City are operated by several airlines — Copa Airlines, Avianca, and Aerolíneas Mas. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $146, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.

The cost of a one-way flight from Cancun to Panama City ranges from $146 (December 2025) to $290 (January 2026). On average, the ticket price is about $218–$290.