Cheap Flights from Guatemala City to Panama City Starting at $131

The distance between Guatemala City and Panama City is 1349km (836 miles). The average flight duration is 2h 24m. There are 45 direct flights from Guatemala City to Panama City. The time difference between Guatemala City and Panama City is 1h. Flights from Guatemala City begin at 4:21 AM. The latest flight from Guatemala City departs at 2:41 AM

Looking for direct flights from Guatemala City to Panama City? Good news! You can easily find direct flights connecting these two vibrant Latin American destinations. Multiple airlines operate non-stop flights on this route, ensuring a convenient travel experience for passengers. Whether you're planning a business trip or exploring the wonders of Panama, direct flights offer a hassle-free journey with no layovers or transfers. However, if there are no direct flights available, don't worry. There are alternative routes with transfers that you can consider. Connecting flights via other major cities in the region, such as San Salvador or Mexico City, offer viable options to reach your destination efficiently. To find the best air ticket deals and compare prices, just enter your travel dates on our website and let us do the work for you. Book your flight now and get ready to embark on an unforgettable journey from Guatemala City to Panama City.

The Guatemala City — Panama City route is served by multiple airlines, including Copa Airlines and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $131, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.

In different months, ticket prices from Guatemala City to Panama City vary: minimum — $131 (December 2025), maximum — $154 (January 2026). Typically, the flight costs $143–$154.