starting at $157
starting at $120
Compare airlines, prices, and flight durations for your trip
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Guatemala City to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Guatemala City to Panama City:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The Guatemala City — Panama City route is served by multiple airlines, including Copa Airlines and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $120, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
starting at $157
starting at $120
Looking for direct flights from Guatemala City to Panama City? Good news! You can easily find direct flights connecting these two vibrant Latin American destinations. Multiple airlines operate non-stop flights on this route, ensuring a convenient travel experience for passengers. Whether you're planning a business trip or exploring the wonders of Panama, direct flights offer a hassle-free journey with no layovers or transfers. However, if there are no direct flights available, don't worry. There are alternative routes with transfers that you can consider. Connecting flights via other major cities in the region, such as San Salvador or Mexico City, offer viable options to reach your destination efficiently. To find the best air ticket deals and compare prices, just enter your travel dates on our website and let us do the work for you. Book your flight now and get ready to embark on an unforgettable journey from Guatemala City to Panama City.
Guatemala City — Panama City
02/06/2026
Departure
Direct flight
CM384
starting at $262
Guatemala City — Panama City
02/09/2026
Departure
Direct flight
CM389
starting at $170
Guatemala City — Panama City
02/10/2026
Departure
Direct flight
CM407
starting at $256
Guatemala City — Panama City
02/11/2026
Departure
Direct flight
CM407
starting at $243
Guatemala City — Panama City
02/13/2026
Departure
Direct flight
CM183
starting at $158
Guatemala City — Panama City
02/14/2026
Departure
Direct flight
CM407
starting at $231
Guatemala City — Panama City
02/15/2026
Departure
Direct flight
CM389
starting at $158
Guatemala City — Panama City
02/04/2026
Departure
Direct flight
CM111
starting at $191
Guatemala City — Panama City
02/05/2026
Departure
Direct flight
CM111
starting at $244
Guatemala City — Panama City
02/07/2026
Departure
Direct flight
CM407
starting at $257
Copa Airlines
Every day
starting at $118
The cheapest one-way flight from Guatemala City to Panama City departs on 03/24/2026, is operated by Avianca and costs $120
The cheapest roundtrip flight from Guatemala City to Panama City departs on 02/16/2026, is operated by Avianca and costs $253
Fastest flight from Guatemala City to Panama City takes 6h 25m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Guatemala City and Panama City is 1349km (836 miles). The average flight duration is 2h 24m. There are 45 direct flights from Guatemala City to Panama City. The time difference between Guatemala City and Panama City is 1h. Flights from Guatemala City begin at 4:21 AM. The latest flight from Guatemala City departs at 2:41 AM
We couldn't find any special offers for flights from Guatemala City to Panama City
The cheapest flight ticket from Guatemala City to Panama City according to data for the last 48 hours costs $120
Often the best time to buy tickets from Guatemala City to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Guatemala City to Panama City can be found flying in these months: February, March, April.
The fastest flights from Guatemala City to Panama City start from 6 hours 25 minutes in the air.
The following airlines operate direct flights on the route Guatemala City — Panama City: Copa Airlines
In different months, ticket prices from Guatemala City to Panama City vary: minimum — $124 (February 2026), maximum — $149 (April 2026). Typically, the flight costs $133–$276.