Copa Airlines
Every day
starting at $238
Compare airlines, prices, and flight durations for your trip
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Guayaquil to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Guayaquil to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Guayaquil to Panama City:
•
•
•
•
•
•
Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Copa Airlines
Every day
starting at $238
Guayaquil — Panama City
01/29/2026
Departure
Direct flight
CM379
starting at $228
Guayaquil — Panama City
02/03/2026
Departure
Direct flight
CM379
starting at $294
Guayaquil — Panama City
02/28/2026
Departure
Direct flight
CM272
starting at $190
Guayaquil — Panama City
03/01/2026
Departure
Direct flight
CM214
starting at $265
Guayaquil — Panama City
03/03/2026
Departure
Direct flight
CM313
starting at $190
Guayaquil — Panama City
04/16/2026
Departure
Direct flight
CM379
starting at $200
starting at $190
starting at $158
The route Guayaquil — Panama City is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $158 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest one-way flight from Guayaquil to Panama City departs on 02/03/2026, is operated by Avianca and costs $158
The cheapest roundtrip flight from Guayaquil to Panama City departs on 02/03/2026, is operated by Avianca and costs $309
Fastest flight from Guayaquil to Panama City takes 4h 55m
There are direct flights on this route 4 days a week: Su, Tu, Th, and Sa
The distance between Guayaquil and Panama City is 1238km (768 miles). The average flight duration is 2h 11m. There are 40 direct flights from Guayaquil to Panama City. Guayaquil and Panama City are in the same time zone. Flights from Guayaquil begin at 4:32 AM. The latest flight from Guayaquil departs at 6:34 PM
The cheapest flight ticket from Guayaquil to Panama City according to data for the last 48 hours costs $158
Often the best time to buy tickets from Guayaquil to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Guayaquil to Panama City can be found flying in these months: February, January, March.
The fastest flights from Guayaquil to Panama City start from 4 hours 55 minutes in the air.
The following airlines operate direct flights on the route Guayaquil — Panama City: Copa Airlines
The minimum one-way ticket price from Guayaquil to Panama City is $158 (February 2026), while the maximum is $185 (March 2026). On average, a ticket costs $171–$355.
