Unable to find information about the schedule of direct flights from
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Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Madrid to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Madrid to Panama City:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Unable to find information about the schedule of direct flights from
Madrid — Panama City
02/03/2026
Departure
Direct flight
UX55
starting at $716
Madrid — Panama City
02/04/2026
Departure
Direct flight
UX55
starting at $614
Madrid — Panama City
02/09/2026
Departure
Direct flight
UX55
starting at $666
Madrid — Panama City
02/21/2026
Departure
Direct flight
IB257
starting at $723
Madrid — Panama City
02/26/2026
Departure
Direct flight
UX55
starting at $552
Madrid — Panama City
03/03/2026
Departure
Direct flight
UX55
starting at $568
Madrid — Panama City
03/14/2026
Departure
Direct flight
UX55
starting at $568
Madrid — Panama City
03/28/2026
Departure
Direct flight
UX55
starting at $820
Madrid — Panama City
04/17/2026
Departure
Direct flight
UX55
starting at $575
Madrid — Panama City
02/18/2026
Departure
Direct flight
IB257
starting at $757
Flights from Madrid to Panama City are operated by several airlines — Air Europa, Iberia, and Avianca. This allows passengers to flexibly choose flights based on departure time, cost, and additional services. The minimum ticket price starts at $350, making this destination accessible to travelers with different budgets. We help compare all available options in real time, so you can book tickets at the best value for money. The service ensures transparent search and lets you book affordable flights in just a few clicks.
The cheapest one-way flight from Madrid to Panama City departs on 03/08/2026, is operated by Avianca and costs $350
The cheapest roundtrip flight from Madrid to Panama City departs on 05/10/2026, is operated by Air Europa and costs $695
Fastest flight from Madrid to Panama City takes 13h 25m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Madrid and Panama City is 8161km (5060 miles). There are 11 direct flights from Madrid to Panama City. The time difference between Madrid and Panama City is 6h. Flights from Madrid begin at 11:40 AM. The latest flight from Madrid departs at 3:10 PM
The cheapest flight ticket from Madrid to Panama City according to data for the last 48 hours costs $350
Often the best time to buy tickets from Madrid to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Panama City can be found flying in these months: March, April, February.
The fastest flights from Madrid to Panama City start from 13 hours 25 minutes in the air.
The following airlines operate direct flights on the route Madrid — Panama City: Air Europa, Iberia
The cost of a one-way flight from Madrid to Panama City ranges from $350 (March 2026) to $457 (July 2026). On average, the ticket price is about $383–$393.
We couldn't find any special offers for flights from Madrid to Panama City