Unable to find information about the schedule of direct flights from
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Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Medellin to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Medellin to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Medellin to Panama City:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Unable to find information about the schedule of direct flights from
Medellin — Panama City
01/29/2026
Departure
Direct flight
CM398
starting at $412
Medellin — Panama City
01/31/2026
Departure
Direct flight
CM154
starting at $690
Medellin — Panama City
02/03/2026
Departure
Direct flight
CM757
starting at $328
Medellin — Panama City
02/05/2026
Departure
Direct flight
P5506
starting at $158
Medellin — Panama City
02/06/2026
Departure
Direct flight
CM154
starting at $228
Medellin — Panama City
02/07/2026
Departure
Direct flight
CM157
starting at $341
Medellin — Panama City
02/08/2026
Departure
Direct flight
CM157
starting at $431
Medellin — Panama City
02/13/2026
Departure
Direct flight
CM157
starting at $158
starting at $158
starting at $158
starting at $165
starting at $253
The Medellin — Panama City route is served by a wide range of airlines: 4 in total, including Copa Airlines, Aerorepublica, Avianca, and B&H Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $158. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.
The cheapest one-way flight from Medellin to Panama City departs on 02/13/2026, is operated by Copa Airlines and costs $158
The cheapest roundtrip flight from Medellin to Panama City departs on 03/28/2026, is operated by Copa Airlines and costs $255
Fastest flight from Medellin to Panama City takes 1h 24m
There are direct flights on this route 5 days a week: Su, Tu, Th, Fr, and Sa
The distance between Medellin and Panama City is 531km (329 miles). The average flight duration is 1h 28m. There are 72 direct flights from Medellin to Panama City. Medellin and Panama City are in the same time zone. Flights from Medellin begin at 5:00 AM. The latest flight from Medellin departs at 6:20 PM
We couldn't find any special offers for flights from Medellin to Panama City
The cheapest flight ticket from Medellin to Panama City according to data for the last 48 hours costs $158
Often the best time to buy tickets from Medellin to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Medellin to Panama City can be found flying in these months: February, January.
The fastest flights from Medellin to Panama City start from 1 hour 24 minutes in the air.
The following airlines operate direct flights on the route Medellin — Panama City: Copa Airlines, Aerorepublica
The minimum one-way ticket price from Medellin to Panama City is $158 (February 2026), while the maximum is $165 (January 2026). On average, a ticket costs $161–$165.
