Starting at $212
Starting at $133
Starting at $164
Starting at $253
Starting at $286
Helping travelers to find the best flight offers
A direct flight is the most convenient and comfortable way to fly from Mexico City to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mexico City to Panama City:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Looking for cheap flights from Mexico City to Panama City? Look no further! Our air ticket search website offers a wide range of affordable options to suit your travel needs. Explore the vibrant beauty of Panama City without breaking the bank. Discover the iconic Panama Canal, stroll through the charming streets of Casco Viejo, or indulge in mouthwatering seafood at the famous Mercado de Mariscos. With our user-friendly platform, you can easily compare prices, airlines, and travel dates to find the best deal. Whether you're planning a relaxing vacation, a business trip, or an adventure-filled getaway, our website ensures you enjoy a hassle-free booking experience. Take advantage of our exclusive discounts and special offers and secure your seats on the next available flight from Mexico City to Panama City. Start your journey now and make unforgettable memories in Panama City!
The route Mexico City — Panama City is served by many carriers — 5 in total, including Copa Airlines, Aeromexico, Avianca, Air Ocean, and VivaAerobus. This gives passengers wide opportunities: from finding the lowest fare (from $133) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
Starting at $212
Starting at $133
Starting at $164
Starting at $253
Starting at $286
Mexico City — Panama City
12/07/2025
Departure
Direct flight
CM195
Starting at $528
Mexico City — Panama City
12/09/2025
Departure
Direct flight
CM857
Starting at $432
Mexico City — Panama City
12/11/2025
Departure
Direct flight
CM149
Starting at $556
Mexico City — Panama City
12/16/2025
Departure
Direct flight
CM137
Starting at $575
Mexico City — Panama City
12/25/2025
Departure
Direct flight
AM464
Starting at $183
Mexico City — Panama City
01/05/2026
Departure
Direct flight
CM857
Starting at $660
Mexico City — Panama City
01/08/2026
Departure
Direct flight
AM464
Starting at $248
Mexico City — Panama City
01/09/2026
Departure
Direct flight
CM121
Starting at $538
Mexico City — Panama City
01/14/2026
Departure
Direct flight
CM149
Starting at $533
Mexico City — Panama City
01/15/2026
Departure
Direct flight
CM121
Starting at $212
The cheapest one-way flight from Mexico City to Panama City departs on 12/25/2025, is operated by Aeromexico and costs $133
The cheapest roundtrip flight from Mexico City to Panama City departs on 01/19/2026, is operated by Aeromexico and costs $354
Fastest flight from Mexico City to Panama City takes 3h 45m
There are direct flights on this route 3 days a week: Mo, Th, and Fr
The distance between Mexico City and Panama City is 2407km (1492 miles). The average flight duration is 3h 46m. There are 55 direct flights from Mexico City to Panama City. The time difference between Mexico City and Panama City is 1h. Flights from Mexico City begin at 5:55 AM. The latest flight from Mexico City departs at 2:00 AM
Copa Airlines
Every day
Starting at $213
We couldn't find any special offers for flights from Mexico City to Panama City
The cheapest flight ticket from Mexico City to Panama City according to data for the last 48 hours costs $133
Often the best time to buy tickets from Mexico City to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Panama City can be found flying in these months: December, January.
The fastest flights from Mexico City to Panama City start from 3 hours 45 minutes in the air.
The following airlines operate direct flights on the route Mexico City — Panama City: Copa Airlines, Aeromexico
In different months, ticket prices from Mexico City to Panama City vary: minimum — $133 (December 2025), maximum — $178 (January 2026). Typically, the flight costs $156–$178.