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Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Mexico City to Santa Cruz. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Mexico City to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mexico City to Santa Cruz:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Unable to find information about the schedule of direct flights from
We couldn't find any special offers for flights from Mexico City to Santa Cruz
There appear to be no non-stop flights from Mexico City to Santa Cruz at this time.... Well, or something went wrong on our side and we couldn't find anything
starting at $267
On the Mexico City — Santa Cruz route, flights are operated only by Avianca. This simplifies the choice for passengers, as all tickets come from a single trusted carrier. Our service lets you instantly check fares for upcoming dates and find the most advantageous option. The minimum ticket price starts at $267, making this trip affordable for a wide range of travelers. To save even more, we recommend booking early and keeping an eye on promotions — Avianca regularly offers special deals.
The cheapest one-way flight from Mexico City to Santa Cruz departs on 04/18/2026, is operated by Avianca and costs $267
The cheapest roundtrip flight from Mexico City to Santa Cruz departs on 02/12/2026, is operated by Avianca and costs $875
Fastest flight from Mexico City to Santa Cruz takes 9h 50m
There are no direct flights on this route.
The distance between Mexico City and Santa Cruz is 5701km (3535 miles). The time difference between Mexico City and Santa Cruz is 2h
The cheapest flight ticket from Mexico City to Santa Cruz according to data for the last 48 hours costs $267
Often the best time to buy tickets from Mexico City to Santa Cruz is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Mexico City to Santa Cruz can be found flying in these months: April, March.
The fastest flights from Mexico City to Santa Cruz start from 9 hours 50 minutes in the air.
The following airlines operate direct flights on the route Mexico City — Santa Cruz:
The cost of a one-way flight from Mexico City to Santa Cruz ranges from $267 (April 2026) to $271 (March 2026). On average, the ticket price is about $269–$271.