Cheap Flights from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago

Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Mexico City to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.

Cheapest one way flight

$244

Asian Air

1 layover

14h 29m

10/29/2026

The cheapest one-way flight from Mexico City to Santiago departs on 10/29/2026, is operated by Asian Air and costs $244

Cheapest round trip flight

$517

Avianca

1 layover

1d 10h 25m

08/15/2026

The cheapest roundtrip flight from Mexico City to Santiago departs on 08/15/2026, is operated by Avianca and costs $517

The fastest flight

11h 40m

Fastest flight from Mexico City to Santiago takes 11h 40m

Direct flights

Several times a week

There are direct flights on this route 5 days a week: Su, Mo, Tu, We, and Fr

Earliest flight

10:10 AM

Latest flight

7:50 PM

Direct flights count

15

Distance

6611km

Timezone difference

2h

The distance between Mexico City and Santiago is 6611km (4099 miles). There are 15 direct flights from Mexico City to Santiago. The time difference between Mexico City and Santiago is 2h. Flights from Mexico City begin at 10:10 AM. The latest flight from Mexico City departs at 7:50 PM

Remember that on average the ideal time to book flights is 2 months before departure!

Airfare from Mexico City to Santiago by month

In different months, ticket prices from Mexico City to Santiago vary: minimum — $244 (October 2026), maximum — $413 (February 2026). Typically, the flight costs $299–$583.

October 2026

Lowest price

on average:

$244

February 2026

Highest price

on average:

$413

Avg Price

Airlines operating on route

The route Mexico City — Santiago is served by many carriers — 6 in total, including Aeromexico, LATAM Chile, Asian Air, Avianca, Volaris, and VivaAerobus. This gives passengers wide opportunities: from finding the lowest fare (from $244) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.

starting at $274

starting at $734

starting at $244

starting at $256

starting at $262

starting at $300

Non-stop flights from Mexico City to Santiago

A non-stop flight is the most convenient and comfortable way to fly from Mexico City to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.

Mexico City — Santiago

MEX — SCL

02/03/2026

Departure

Direct flight

AM10

starting at $746

Mexico City — Santiago

MEX — SCL

02/23/2026

Departure

Direct flight

AM10

starting at $1,082

Mexico City — Santiago

MEX — SCL

03/13/2026

Departure

Direct flight

LA621

starting at $910

Mexico City — Santiago

MEX — SCL

03/22/2026

Departure

Direct flight

LA621

starting at $917

Mexico City — Santiago

MEX — SCL

03/23/2026

Departure

Direct flight

LA621

starting at $734

Mexico City — Santiago

MEX — SCL

03/23/2026

Departure

Direct flight

AM10

starting at $274

Mexico City — Santiago

MEX — SCL

03/25/2026

Departure

Direct flight

LA621

starting at $830

Mexico City — Santiago

MEX — SCL

03/30/2026

Departure

Direct flight

LA621

starting at $804

Mexico City — Santiago

MEX — SCL

06/24/2026

Departure

Direct flight

LA621

starting at $793

Mexico City — Santiago

MEX — SCL

10/30/2026

Departure

Direct flight

LA621

starting at $966

Schedule of direct flights from Mexico City to Santiago

A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Mexico City to Santiago:

Unable to find information about the schedule of direct flights from

Mexico City airports overview

Benito Juarez International Airport

•

MEX

6km

Felipe Angeles International Airport

•

NLU

4km

Toluca International Airport

•

TLC

59km

•

Santiago airports overview

Arturo Merino Benitez Airport

•

SCL

23km

•

Frequently asked questions (FAQ)

Answers to questions about the route that travelers are most interested in.

What is the cheapest price for flights from Mexico City to Santiago?

The cheapest flight ticket from Mexico City to Santiago according to data for the last 48 hours costs $244

When is the best time to buy air tickets on the route Mexico City — Santiago?

Often the best time to buy tickets from Mexico City to Santiago is 2 months before departure.

When is the cheapest time of year to fly from Mexico City to Santiago?

Based on statistics over the past years, the lowest prices for flights from Mexico City to Santiago can be found flying in these months: October, March, November.

How long does it take to fly from Mexico City to Santiago?

The fastest flights from Mexico City to Santiago start from 11 hours 40 minutes in the air.

Which airline can fly direct from Mexico City to Santiago?

The following airlines operate direct flights on the route Mexico City — Santiago: Aeromexico, LATAM Chile

Special offers and sales on air tickets from Mexico City to Santiago

We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.

We couldn't find any special offers for flights from Mexico City to Santiago

Alternative routes

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Cheapest one way flight

$244

Asian Air

1 layover

14h 29m

10/29/2026

The cheapest one-way flight from Mexico City to Santiago departs on 10/29/2026, is operated by Asian Air and costs $244

Cheapest round trip flight

$517

Avianca

1 layover

1d 10h 25m

08/15/2026

The cheapest roundtrip flight from Mexico City to Santiago departs on 08/15/2026, is operated by Avianca and costs $517

The fastest flight