A direct flight is the most convenient and comfortable way to fly from Panama City to Knoxville, despite the fact that sometimes flights with transfers can cost significantly less.
Schedule of direct flights from Panama City to Knoxville
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Knoxville:
Panama City airports overview
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Knoxville airports overview
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Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Panama City to Knoxville
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$121
Southwest Airlines
2 transfers
6h 55m
09/28/2026
The cheapest one-way flight from Panama City to Knoxville departs on 09/28/2026, is operated by Southwest Airlines and costs $121
Cheapest round trip flight
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There is no information about the cheapest roundtrip flight from Panama City to Knoxville
The fastest flight
3h 29m
Fastest flight from Panama City to Knoxville takes 3h 29m
Direct flights
No direct flights
There are no direct flights on this route.
Distance
646km
Timezone difference
1h
The distance between Panama City and Knoxville is 646km (401 miles). The time difference between Panama City and Knoxville is 1h
The Panama City — Knoxville route is served by multiple airlines, including Southwest Airlines and American Airlines. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $121, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
There appear to be no direct flights from Panama City to Knoxville at this time.... Well, or something went wrong on our side and we couldn't find anything
Unable to find information about the schedule of direct flights from
We couldn't find any special offers for flights from Panama City to Knoxville
How much is the cheapest flight ticket from Panama City to Knoxville?
The cheapest flight ticket from Panama City to Knoxville according to data for the last 48 hours costs $121
When is the best time to buy air tickets on the route Panama City — Knoxville?
Often the best time to buy tickets from Panama City to Knoxville is 2 months before departure.
When is the cheapest time of year to fly from Panama City to Knoxville?
Based on statistics over the past years, the lowest prices for flights from Panama City to Knoxville can be found flying in these months: October.
How long does it take to fly from Panama City to Knoxville?
The fastest flights from Panama City to Knoxville start from 3 hours 29 minutes in the air.
Which airline can fly direct from Panama City to Knoxville?
The following airlines operate direct flights on the route Panama City — Knoxville:
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Panama City to Knoxville
