Helping travelers to find the best flight offers
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Panama City to Guayaquil. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Guayaquil:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The cheapest one-way flight from Panama City to Guayaquil departs on 12/11/2025, is operated by Avianca and costs $176
There is no information about the cheapest roundtrip flight from Panama City to Guayaquil
Fastest flight from Panama City to Guayaquil takes 4h 45m
There are no direct flights on this route.
The distance between Panama City and Guayaquil is 1238km (768 miles). There are 40 direct flights from Panama City to Guayaquil. Panama City and Guayaquil are in the same time zone. Flights from Panama City begin at 9:02 AM. The latest flight from Panama City departs at 9:24 PM
A direct flight is the most convenient and comfortable way to fly from Panama City to Guayaquil, despite the fact that sometimes flights with transfers can cost significantly less.
Copa Airlines
Every day
Starting at $282
Panama City — Guayaquil
12/11/2025
Departure
Direct flight
CM213
Starting at $264
Panama City — Guayaquil
12/14/2025
Departure
Direct flight
CM213
Starting at $813
Panama City — Guayaquil
01/07/2026
Departure
Direct flight
CM301
Starting at $798
Panama City — Guayaquil
01/08/2026
Departure
Direct flight
CM301
Starting at $353
Starting at $264
Starting at $176
The Panama City — Guayaquil route is served by multiple airlines, including Copa Airlines and Avianca. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $176, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
We couldn't find any special offers for flights from Panama City to Guayaquil
The cheapest flight ticket from Panama City to Guayaquil according to data for the last 48 hours costs $176
Often the best time to buy tickets from Panama City to Guayaquil is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Guayaquil can be found flying in these months: December, January.
The fastest flights from Panama City to Guayaquil start from 4 hours 45 minutes in the air.
The following airlines operate direct flights on the route Panama City — Guayaquil: Copa Airlines
In different months, ticket prices from Panama City to Guayaquil vary: minimum — $176 (December 2025), maximum — $182 (January 2026). Typically, the flight costs $179–$182.