Compare airlines, prices, and flight durations for your trip
A non-stop flight is the most convenient and comfortable way to fly from Panama City to Mexico City, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Mexico City:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Looking for cheap flights from Panama City to Mexico City? Look no further! Our air ticket search website is here to help you find the best deals on your next trip. Whether you're planning a business trip or a vacation, we've got you covered. With our user-friendly search engine, you can compare prices from multiple airlines and choose the one that fits your budget. Explore the vibrant streets of Mexico City, visit its historical sites, or indulge in its delicious cuisine without breaking the bank. Don't miss out on this incredible opportunity. Start booking your affordable flight from Panama City to Mexico City today and embark on an unforgettable journey.
The route Panama City — Mexico City is served by several airlines: Copa Airlines, Aeromexico, and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $234 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
Panama City — Mexico City
02/07/2026
Departure
Direct flight
CM120
starting at $541
Panama City — Mexico City
02/09/2026
Departure
Direct flight
CM138
starting at $421
Panama City — Mexico City
02/10/2026
Departure
Direct flight
AM465
starting at $532
Panama City — Mexico City
02/12/2026
Departure
Direct flight
CM194
starting at $421
Panama City — Mexico City
03/18/2026
Departure
Direct flight
CM138
starting at $481
Panama City — Mexico City
02/08/2026
Departure
Direct flight
CM120
starting at $421
Panama City — Mexico City
02/14/2026
Departure
Direct flight
CM136
starting at $641
Panama City — Mexico City
02/22/2026
Departure
Direct flight
CM194
starting at $541
Panama City — Mexico City
02/24/2026
Departure
Direct flight
CM120
starting at $542
Panama City — Mexico City
02/26/2026
Departure
Direct flight
CM194
starting at $542
Aeromexico
Tu and We
starting at $532
We couldn't find any special offers for flights from Panama City to Mexico City
The cheapest one-way flight from Panama City to Mexico City departs on 02/14/2026, is operated by Avianca and costs $234
The cheapest roundtrip flight from Panama City to Mexico City departs on 03/05/2026, is operated by Avianca and costs $346
Fastest flight from Panama City to Mexico City takes 8h 55m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Panama City and Mexico City is 2407km (1492 miles). There are 6 direct flights from Panama City to Mexico City. The time difference between Panama City and Mexico City is 1h. Flights from Panama City begin at 9:21 AM. The latest flight from Panama City departs at 9:25 PM
The cheapest flight ticket from Panama City to Mexico City according to data for the last 48 hours costs $234
Often the best time to buy tickets from Panama City to Mexico City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Mexico City can be found flying in these months: March, February, April.
The fastest flights from Panama City to Mexico City start from 8 hours 55 minutes in the air.
The following airlines operate direct flights on the route Panama City — Mexico City: Copa Airlines, Aeromexico
The minimum one-way ticket price from Panama City to Mexico City is $247 (March 2026), while the maximum is $277 (August 2026). On average, a ticket costs $266–$272.