Starting at $843
Starting at $356
Helping travelers to find the best flight offers
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Panama City to Santa Cruz. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A direct flight is the most convenient and comfortable way to fly from Panama City to Santa Cruz, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Santa Cruz:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The route Panama City — Santa Cruz is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $356 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
Starting at $843
Starting at $356
Panama City — Santa Cruz
12/20/2025
Departure
Direct flight
CM221
Starting at $1,184
Panama City — Santa Cruz
01/24/2026
Departure
Direct flight
CM127
Starting at $843
Unable to find information about the schedule of direct flights from
The cheapest one-way flight from Panama City to Santa Cruz departs on 01/24/2026, is operated by Avianca and costs $356
There is no information about the cheapest roundtrip flight from Panama City to Santa Cruz
Fastest flight from Panama City to Santa Cruz takes 10h 40m
There are no direct flights on this route.
The distance between Panama City and Santa Cruz is 3475km (2155 miles). There are 13 direct flights from Panama City to Santa Cruz. The time difference between Panama City and Santa Cruz is 1h. Flights from Panama City begin at 4:40 PM. The latest flight from Panama City departs at 9:43 PM
We couldn't find any special offers for flights from Panama City to Santa Cruz
The cheapest flight ticket from Panama City to Santa Cruz according to data for the last 48 hours costs $356
Often the best time to buy tickets from Panama City to Santa Cruz is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Panama City to Santa Cruz can be found flying in these months: January.
The fastest flights from Panama City to Santa Cruz start from 10 hours 40 minutes in the air.
The following airlines operate direct flights on the route Panama City — Santa Cruz: Copa Airlines
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Panama City to Santa Cruz