Airfare from Panama City to Santo Domingo by month
Airlines operating on route
Direct Flights from Panama City to Santo Domingo
A direct flight is the most convenient and comfortable way to fly from Panama City to Santo Domingo, despite the fact that sometimes flights with transfers can cost significantly less.
Schedule of direct flights from Panama City to Santo Domingo
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Panama City to Santo Domingo:
Panama City airports overview
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Santo Domingo airports overview
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Frequently asked questions (FAQ)
Answers to questions about the route that travelers are most interested in.
Special offers and sales on air tickets from Panama City to Santo Domingo
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Alternative routes
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Cheapest one way flight
$239
Avianca
1 transfer
12h 55m
12/15/2025
The cheapest one-way flight from Panama City to Santo Domingo departs on 12/15/2025, is operated by Avianca and costs $239
Cheapest round trip flight
$450
Copa Airlines
Direct flight
5h 5m
03/05/2026
The cheapest roundtrip flight from Panama City to Santo Domingo departs on 03/05/2026, is operated by Copa Airlines and costs $450
The fastest flight
6h 5m
Fastest flight from Panama City to Santo Domingo takes 6h 5m
Direct flights
No direct flights
There are no direct flights on this route.
Earliest flight
7:26 AM
Latest flight
11:13 PM
Direct flights count
36
Distance
1474km
Timezone difference
1h
The distance between Panama City and Santo Domingo is 1474km (914 miles). There are 36 direct flights from Panama City to Santo Domingo. The time difference between Panama City and Santo Domingo is 1h. Flights from Panama City begin at 7:26 AM. The latest flight from Panama City departs at 11:13 PM
December 2025
Lowest price
on average:
$261
January 2026
Highest price
on average:
$528
Avg Price
The route Panama City — Santo Domingo is served by several airlines: Copa Airlines and Avianca. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $239 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
We couldn't find any special offers for flights from Panama City to Santo Domingo
How much is the cheapest flight ticket from Panama City to Santo Domingo?
The cheapest flight ticket from Panama City to Santo Domingo according to data for the last 48 hours costs $239
When is the best time to buy air tickets on the route Panama City — Santo Domingo?
Often the best time to buy tickets from Panama City to Santo Domingo is 2 months before departure.
When is the cheapest time of year to fly from Panama City to Santo Domingo?
Based on statistics over the past years, the lowest prices for flights from Panama City to Santo Domingo can be found flying in these months: December, January.
How long does it take to fly from Panama City to Santo Domingo?
The fastest flights from Panama City to Santo Domingo start from 6 hours 5 minutes in the air.
Which airline can fly direct from Panama City to Santo Domingo?
The following airlines operate direct flights on the route Panama City — Santo Domingo: Copa Airlines
The minimum one-way ticket price from Panama City to Santo Domingo is $261 (December 2025), while the maximum is $528 (January 2026). On average, a ticket costs $395–$528.
