There are most likely no direct flights on the Santa Cruz — Santiago route
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A non-stop flight is the most convenient and comfortable way to fly from Santa Cruz to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
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Answers to questions about the route that travelers are most interested in.
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There are most likely no direct flights on the Santa Cruz — Santiago route
We couldn't find any special offers for flights from Santa Cruz to Santiago
Santa Cruz — Santiago
06/13/2026
Departure
Direct flight
OB1722
starting at $262
Santa Cruz — Santiago
09/30/2026
Departure
Direct flight
LA865
starting at $351
starting at $262
starting at $351
The Santa Cruz — Santiago route is served by multiple airlines, including Boliviana de Aviación and LATAM Chile. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $262, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
The cheapest one-way flight from Santa Cruz to Santiago departs on 06/13/2026, is operated by Boliviana de Aviación and costs $262
There is no information about the cheapest roundtrip flight from Santa Cruz to Santiago
Fastest flight from Santa Cruz to Santiago takes 3h 15m
There are direct flights on this route 2 days a week: We and Sa
The distance between Santa Cruz and Santiago is 1886km (1169 miles). There are 1 direct flight from Santa Cruz to Santiago. Santa Cruz and Santiago are in the same time zone. Flights from Santa Cruz begin at 9:15 PM. The latest flight from Santa Cruz departs at 9:15 PM
The cheapest flight ticket from Santa Cruz to Santiago according to data for the last 48 hours costs $262
Often the best time to buy tickets from Santa Cruz to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santa Cruz to Santiago can be found flying in these months: June, September.
The fastest flights from Santa Cruz to Santiago start from 3 hours 15 minutes in the air.
The following airlines operate direct flights on the route Santa Cruz — Santiago: Boliviana de Aviación, LATAM Chile
In different months, ticket prices from Santa Cruz to Santiago vary: minimum — $262 (June 2026), maximum — $346 (September 2026). Typically, the flight costs $304–$346.