starting at $319
starting at $461
Compare airlines, prices, and flight durations for your trip
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santa Cruz to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Santa Cruz to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santa Cruz to Santiago:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The Santa Cruz — Santiago route is served by multiple airlines, including LATAM Chile and Boliviana de Aviación. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $319, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.
starting at $319
starting at $461
Santa Cruz — Santiago
02/04/2026
Departure
Direct flight
LA865
starting at $445
Santa Cruz — Santiago
03/28/2026
Departure
Direct flight
LA890
starting at $319
Santa Cruz — Santiago
04/08/2026
Departure
Direct flight
LA865
starting at $319
Unable to find information about the schedule of direct flights from
The cheapest one-way flight from Santa Cruz to Santiago departs on 03/28/2026, is operated by LATAM Chile and costs $319
There is no information about the cheapest roundtrip flight from Santa Cruz to Santiago
Fastest flight from Santa Cruz to Santiago takes 3h 2m
There are direct flights on this route 2 days a week: We and Sa
The distance between Santa Cruz and Santiago is 1886km (1169 miles). There are 6 direct flights from Santa Cruz to Santiago. Santa Cruz and Santiago are in the same time zone. Flights from Santa Cruz begin at 7:26 AM. The latest flight from Santa Cruz departs at 11:15 AM
We couldn't find any special offers for flights from Santa Cruz to Santiago
The cheapest flight ticket from Santa Cruz to Santiago according to data for the last 48 hours costs $319
Often the best time to buy tickets from Santa Cruz to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santa Cruz to Santiago can be found flying in these months: March, April, February.
The fastest flights from Santa Cruz to Santiago start from 3 hours 2 minutes in the air.
The following airlines operate direct flights on the route Santa Cruz — Santiago: LATAM Chile
In different months, ticket prices from Santa Cruz to Santiago vary: minimum — $319 (March 2026), maximum — $461 (February 2026). Typically, the flight costs $366–$780.