Cheap Flights from Santa Cruz to Santiago

Cheapest flights from Santa Cruz to Santiago

Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santa Cruz to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.

Cheapest one way flight

$426

Boliviana de Aviación

1 transfer

13h 45m

12/11/2025

The cheapest one-way flight from Santa Cruz to Santiago departs on 12/11/2025, is operated by Boliviana de Aviación and costs $426

Cheapest round trip flight

$505

Silk Way Airlines

2 transfers

1d 1h 29m

02/18/2026

The cheapest roundtrip flight from Santa Cruz to Santiago departs on 02/18/2026, is operated by Silk Way Airlines and costs $505

The fastest flight

13h 45m

Fastest flight from Santa Cruz to Santiago takes 13h 45m

Direct flights

No direct flights

There are no direct flights on this route.

Earliest flight

7:26 AM

Latest flight

11:15 AM

Direct flights count

6

Distance

1886km

Timezone difference

0h

The distance between Santa Cruz and Santiago is 1886km (1169 miles). There are 6 direct flights from Santa Cruz to Santiago. Santa Cruz and Santiago are in the same time zone. Flights from Santa Cruz begin at 7:26 AM. The latest flight from Santa Cruz departs at 11:15 AM

Remember that on average the ideal time to book flights is 2 months before departure!

Airfare from Santa Cruz to Santiago by month

We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Santa Cruz to Santiago

December 2025

Lowest price

on average:

$426

Avg Price

Airlines operating on route

The Santa Cruz — Santiago route is served by multiple airlines, including LATAM Chile and Boliviana de Aviación. This is convenient for those who want the best balance of price, schedule, and travel conditions. Tickets start from $426, and depending on season and promotions, even better deals may appear. With our service, you can easily compare available options and book tickets that match your plans. The variety of carriers allows flexible choices and comfortable travel without overpaying.

LATAM Chile

Starting at $593

Boliviana de Aviación

Starting at $426

Direct Flights from Santa Cruz to Santiago

A direct flight is the most convenient and comfortable way to fly from Santa Cruz to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.

Santa Cruz — Santiago

SRZ — SCL

12/10/2025

Departure

Direct flight

LA865

Starting at $593

Schedule of direct flights from Santa Cruz to Santiago

A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santa Cruz to Santiago:

Unable to find information about the schedule of direct flights from

Santa Cruz airports overview

Viru Viru International Airport

•

VVI

17km

•

Santiago airports overview

Arturo Merino Benitez Airport

•

SCL

23km

•

Frequently asked questions (FAQ)

Answers to questions about the route that travelers are most interested in.

How much is the cheapest flight ticket from Santa Cruz to Santiago?

The cheapest flight ticket from Santa Cruz to Santiago according to data for the last 48 hours costs $426

When is the best time to buy air tickets on the route Santa Cruz — Santiago?

Often the best time to buy tickets from Santa Cruz to Santiago is 2 months before departure.

When is the cheapest time of year to fly from Santa Cruz to Santiago?

Based on statistics over the past years, the lowest prices for flights from Santa Cruz to Santiago can be found flying in these months: December.

How long does it take to fly from Santa Cruz to Santiago?

The fastest flights from Santa Cruz to Santiago start from 13 hours 45 minutes in the air.

Which airline can fly direct from Santa Cruz to Santiago?

The following airlines operate direct flights on the route Santa Cruz — Santiago: LATAM Chile

Special offers and sales on air tickets from Santa Cruz to Santiago

We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.

We couldn't find any special offers for flights from Santa Cruz to Santiago

Alternative routes

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Cheapest one way flight

$426

Boliviana de Aviación

1 transfer

13h 45m

12/11/2025

The cheapest one-way flight from Santa Cruz to Santiago departs on 12/11/2025, is operated by Boliviana de Aviación and costs $426

Cheapest round trip flight

$505

Silk Way Airlines

2 transfers

1d 1h 29m

02/18/2026

The cheapest roundtrip flight from Santa Cruz to Santiago departs on 02/18/2026, is operated by Silk Way Airlines and costs $505

The fastest flight