Unable to find information about the schedule of direct flights from
Helping travelers to find the best flight offers
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Guayaquil:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Looking for cheap flights from Santiago, Chile to Guayaquil, Ecuador? Look no further! Our air ticket search website offers a wide range of affordable options for your travel needs. With our user-friendly interface, finding the best deals has never been easier. Fly from Santiago, Chile to Guayaquil, Ecuador and explore the vibrant cultural scene, picturesque landscapes, and delicious cuisine that this South American destination has to offer. Whether you're traveling for business or pleasure, our website ensures that you can save both time and money on your flight bookings. Book your flight today and embark on an unforgettable journey from Santiago, Chile to Guayaquil, Ecuador. Don't wait - start planning your adventure now with our affordable flight options!
Unable to find information about the schedule of direct flights from
A direct flight is the most convenient and comfortable way to fly from Santiago to Guayaquil, despite the fact that sometimes flights with transfers can cost significantly less.
Santiago — Guayaquil
01/10/2026
Departure
Direct flight
XL1446
Starting at $375
Santiago — Guayaquil
01/11/2026
Departure
Direct flight
LA1446
Starting at $294
Santiago — Guayaquil
01/14/2026
Departure
Direct flight
LA1446
Starting at $261
Santiago — Guayaquil
02/15/2026
Departure
Direct flight
XL1446
Starting at $253
Santiago — Guayaquil
02/16/2026
Departure
Direct flight
LA1446
Starting at $338
Starting at $253
Starting at $261
The route Santiago — Guayaquil is served by several airlines: LATAM Ecuador and LATAM Chile. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $253 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest one-way flight from Santiago to Guayaquil departs on 01/14/2026, is operated by LATAM Chile and costs $261
The cheapest roundtrip flight from Santiago to Guayaquil departs on 02/02/2026, is operated by LATAM Chile and costs $497
Fastest flight from Santiago to Guayaquil takes 5h 18m
There are direct flights on this route 1 day a week: We
The distance between Santiago and Guayaquil is 3610km (2238 miles). There are 8 direct flights from Santiago to Guayaquil. The time difference between Santiago and Guayaquil is 1h. Flights from Santiago begin at 12:45 AM. The latest flight from Santiago departs at 12:45 AM
We couldn't find any special offers for flights from Santiago to Guayaquil
The cheapest flight ticket from Santiago to Guayaquil according to data for the last 48 hours costs $261
Often the best time to buy tickets from Santiago to Guayaquil is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Guayaquil can be found flying in these months: February, January.
The fastest flights from Santiago to Guayaquil start from 5 hours 18 minutes in the air.
The following airlines operate direct flights on the route Santiago — Guayaquil: LATAM Ecuador, LATAM Chile
The minimum one-way ticket price from Santiago to Guayaquil is $218 (February 2026), while the maximum is $261 (January 2026). On average, a ticket costs $240–$261.