Unable to find information about the schedule of direct flights from
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A non-stop flight is the most convenient and comfortable way to fly from Santiago to Guayaquil, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Guayaquil:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Looking for cheap flights from Santiago, Chile to Guayaquil, Ecuador? Look no further! Our air ticket search website offers a wide range of affordable options for your travel needs. With our user-friendly interface, finding the best deals has never been easier. Fly from Santiago, Chile to Guayaquil, Ecuador and explore the vibrant cultural scene, picturesque landscapes, and delicious cuisine that this South American destination has to offer. Whether you're traveling for business or pleasure, our website ensures that you can save both time and money on your flight bookings. Book your flight today and embark on an unforgettable journey from Santiago, Chile to Guayaquil, Ecuador. Don't wait - start planning your adventure now with our affordable flight options!
Unable to find information about the schedule of direct flights from
Santiago — Guayaquil
02/02/2026
Departure
Direct flight
LA1446
starting at $282
Santiago — Guayaquil
02/05/2026
Departure
Direct flight
LA1446
starting at $449
Santiago — Guayaquil
02/10/2026
Departure
Direct flight
XL1446
starting at $560
Santiago — Guayaquil
06/10/2026
Departure
Direct flight
XL1446
starting at $233
Santiago — Guayaquil
11/14/2026
Departure
Direct flight
LA1446
starting at $227
starting at $213
starting at $233
starting at $212
starting at $256
The Santiago — Guayaquil route is served by a wide range of airlines: 4 in total, including LATAM Chile, LATAM Ecuador, Avianca, and Copa Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $212. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.
The cheapest one-way flight from Santiago to Guayaquil departs on 11/14/2026, is operated by Avianca and costs $212
The cheapest roundtrip flight from Santiago to Guayaquil departs on 04/21/2026, is operated by Avianca and costs $429
Fastest flight from Santiago to Guayaquil takes 5h 18m
There are direct flights on this route 5 days a week: Mo, Tu, We, Th, and Sa
The distance between Santiago and Guayaquil is 3610km (2238 miles). There are 8 direct flights from Santiago to Guayaquil. The time difference between Santiago and Guayaquil is 1h. Flights from Santiago begin at 12:45 AM. The latest flight from Santiago departs at 12:45 AM
We couldn't find any special offers for flights from Santiago to Guayaquil
The cheapest flight ticket from Santiago to Guayaquil according to data for the last 48 hours costs $212
Often the best time to buy tickets from Santiago to Guayaquil is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Guayaquil can be found flying in these months: November, June, February.
The fastest flights from Santiago to Guayaquil start from 5 hours 18 minutes in the air.
The following airlines operate direct flights on the route Santiago — Guayaquil: LATAM Chile, LATAM Ecuador
The minimum one-way ticket price from Santiago to Guayaquil is $212 (November 2026), while the maximum is $282 (February 2026). On average, a ticket costs $243–$515.
