starting at $114
starting at $96
Compare airlines, prices, and flight durations for your trip
A non-stop flight is the most convenient and comfortable way to fly from Santo Domingo to Medellin, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santo Domingo to Medellin:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
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The route Santo Domingo — Medellin is served by several airlines: Asian Air and Aerorepublica. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $96 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
starting at $114
starting at $96
Santo Domingo — Medellin
02/01/2026
Departure
Direct flight
DM1736
starting at $225
Santo Domingo — Medellin
02/17/2026
Departure
Direct flight
DM1736
starting at $114
Santo Domingo — Medellin
09/26/2026
Departure
Direct flight
DM1736
starting at $130
Asian Air
Mo
starting at $104
The cheapest one-way flight from Santo Domingo to Medellin departs on 09/26/2026, is operated by Aerorepublica and costs $96
The cheapest roundtrip flight from Santo Domingo to Medellin departs on 09/03/2026, is operated by Aerorepublica and costs $206
Fastest flight from Santo Domingo to Medellin takes 2h 28m
There are direct flights on this route 3 days a week: Su, Tu, and Sa
The distance between Santo Domingo and Medellin is 1492km (925 miles). There are 1 direct flight from Santo Domingo to Medellin. The time difference between Santo Domingo and Medellin is 1h. Flights from Santo Domingo begin at 6:08 PM. The latest flight from Santo Domingo departs at 6:08 PM
We couldn't find any special offers for flights from Santo Domingo to Medellin
The cheapest flight ticket from Santo Domingo to Medellin according to data for the last 48 hours costs $96
Often the best time to buy tickets from Santo Domingo to Medellin is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Medellin can be found flying in these months: September, February.
The fastest flights from Santo Domingo to Medellin start from 2 hours 28 minutes in the air.
The following airlines operate direct flights on the route Santo Domingo — Medellin: Asian Air
The minimum one-way ticket price from Santo Domingo to Medellin is $96 (September 2026), while the maximum is $105 (February 2026). On average, a ticket costs $101–$105.