Asian Air
Mo
starting at $406
Aeromexico
Su, Mo, and Sa
starting at $442
Compare airlines, prices, and flight durations for your trip
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santo Domingo to Mexico City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santo Domingo to Mexico City:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Asian Air
Mo
starting at $406
Aeromexico
Su, Mo, and Sa
starting at $442
A non-stop flight is the most convenient and comfortable way to fly from Santo Domingo to Mexico City, despite the fact that sometimes flights with transfers can cost significantly less.
Santo Domingo — Mexico City
03/21/2026
Departure
Direct flight
AM655
starting at $464
Santo Domingo — Mexico City
03/22/2026
Departure
Direct flight
AM655
starting at $453
Santo Domingo — Mexico City
03/23/2026
Departure
Direct flight
DM4158
starting at $455
starting at $453
starting at $455
starting at $221
starting at $234
The route Santo Domingo — Mexico City is served by many carriers — 4 in total, including Aeromexico, Asian Air, Avianca, and Copa Airlines. This gives passengers wide opportunities: from finding the lowest fare (from $221) to selecting flights by schedule or service class. Our service aggregates data from multiple booking systems so you can compare offers in one place. This saves time and money: no need to check dozens of sites — just pick the right option and book online.
The cheapest one-way flight from Santo Domingo to Mexico City departs on 03/21/2026, is operated by Avianca and costs $221
The cheapest roundtrip flight from Santo Domingo to Mexico City departs on 07/09/2026, is operated by Asian Air and costs $353
Fastest flight from Santo Domingo to Mexico City takes 12h 32m
There are direct flights on this route 3 days a week: Su, Mo, and Sa
The distance between Santo Domingo and Mexico City is 3062km (1898 miles). The average flight duration is 5h 3m. There are 3 direct flights from Santo Domingo to Mexico City. The time difference between Santo Domingo and Mexico City is 2h. Flights from Santo Domingo begin at 11:01 AM. The latest flight from Santo Domingo departs at 7:49 PM
We couldn't find any special offers for flights from Santo Domingo to Mexico City
The cheapest flight ticket from Santo Domingo to Mexico City according to data for the last 48 hours costs $221
Often the best time to buy tickets from Santo Domingo to Mexico City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Mexico City can be found flying in these months: March.
The fastest flights from Santo Domingo to Mexico City start from 12 hours 32 minutes in the air.
The following airlines operate direct flights on the route Santo Domingo — Mexico City: Aeromexico, Asian Air
We carefully collect statistics on the search and pricing of airlines and, based on these data, we make an assumption about future prices. Thus, you can better understand which season is the cheapest to fly from Santo Domingo to Mexico City
