LATAM Chile
Su, Mo, Fr, and Sa
starting at $166
Compare airlines, prices, and flight durations for your trip
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Cuzco to Santiago. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Cuzco to Santiago:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
LATAM Chile
Su, Mo, Fr, and Sa
starting at $166
A non-stop flight is the most convenient and comfortable way to fly from Cuzco to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
Cuzco — Santiago
02/02/2026
Departure
Direct flight
LA2366
starting at $310
Cuzco — Santiago
02/04/2026
Departure
Direct flight
LA2366
starting at $422
Cuzco — Santiago
02/05/2026
Departure
Direct flight
LA2366
starting at $491
Cuzco — Santiago
02/06/2026
Departure
Direct flight
LA2366
starting at $416
Cuzco — Santiago
02/08/2026
Departure
Direct flight
LA2366
starting at $256
Cuzco — Santiago
02/11/2026
Departure
Direct flight
LA2366
starting at $611
Cuzco — Santiago
02/12/2026
Departure
Direct flight
LA2366
starting at $611
Cuzco — Santiago
02/17/2026
Departure
Direct flight
LA2366
starting at $300
Cuzco — Santiago
02/25/2026
Departure
Direct flight
LA2366
starting at $555
Cuzco — Santiago
02/26/2026
Departure
Direct flight
LA2366
starting at $508
starting at $108
starting at $114
starting at $115
starting at $140
More than 4 airlines operate flights from Cuzco to Santiago, including LATAM Chile, Jatayu Airlines, B&H Airlines, and Sky Airline. This is a popular route, so passengers can choose tickets based on budget and preferences. Ticket prices start from $108, and our service lets you instantly compare all options. The variety of offers simplifies planning: you can choose budget fares or more comfortable options with baggage included or extra services. We help you find the best deals so your trip is cost-efficient.
The cheapest one-way flight from Cuzco to Santiago departs on 04/10/2026, is operated by LATAM Chile and costs $108
There is no information about the cheapest roundtrip flight from Cuzco to Santiago
Fastest flight from Cuzco to Santiago takes 2h 20m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Cuzco and Santiago is 2214km (1373 miles). The average flight duration is 4h 43m. There are 11 direct flights from Cuzco to Santiago. The time difference between Cuzco and Santiago is 1h. Flights from Cuzco begin at 9:30 AM. The latest flight from Cuzco departs at 2:40 PM
The cheapest flight ticket from Cuzco to Santiago according to data for the last 48 hours costs $108
Often the best time to buy tickets from Cuzco to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Cuzco to Santiago can be found flying in these months: April, May, March.
The fastest flights from Cuzco to Santiago start from 2 hours 20 minutes in the air.
The following airlines operate direct flights on the route Cuzco — Santiago: LATAM Chile
The cost of a one-way flight from Cuzco to Santiago ranges from $108 (April 2026) to $223 (February 2026). On average, the ticket price is about $142–$291.
