Compare airlines, prices, and flight durations for your trip
A non-stop flight is the most convenient and comfortable way to fly from Madrid to Santiago, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Madrid to Santiago:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
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The Madrid — Santiago route is served by a wide range of airlines: 9 in total, including Iberia, LATAM Chile, Avianca, ITA Airways, Ryanair, Lufthansa, Transavia, Air Canada, and Azul Brazilian Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $378. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.
Madrid — Santiago
03/22/2026
Departure
Direct flight
IB113
starting at $774
Madrid — Santiago
03/23/2026
Departure
Direct flight
IB113
starting at $755
Madrid — Santiago
03/24/2026
Departure
Direct flight
LA705
starting at $512
Madrid — Santiago
03/25/2026
Departure
Direct flight
LA705
starting at $1,066
Madrid — Santiago
03/26/2026
Departure
Direct flight
IB117
starting at $990
Madrid — Santiago
04/03/2026
Departure
Direct flight
LA705
starting at $528
Madrid — Santiago
04/04/2026
Departure
Direct flight
LA707
starting at $452
Madrid — Santiago
04/05/2026
Departure
Direct flight
LA5404
starting at $533
Madrid — Santiago
04/06/2026
Departure
Direct flight
IB117
starting at $529
Madrid — Santiago
04/07/2026
Departure
Direct flight
LA715
starting at $742
LATAM Chile
Su, Mo, Tu, We, Th, and Fr
starting at $504
starting at $500
starting at $434
starting at $378
starting at $512
starting at $521
starting at $593
starting at $598
starting at $610
starting at $666
The cheapest one-way flight from Madrid to Santiago departs on 04/02/2026, is operated by Avianca and costs $378
The cheapest roundtrip flight from Madrid to Santiago departs on 11/25/2026, is operated by Air Canada and costs $822
Fastest flight from Madrid to Santiago takes 12h 20m
There are direct flights on this route 7 days a week: Su, Mo, Tu, We, Th, Fr, and Sa
The distance between Madrid and Santiago is 10691km (6628 miles). There are 20 direct flights from Madrid to Santiago. The time difference between Madrid and Santiago is 5h. Flights from Madrid begin at 11:05 AM. The latest flight from Madrid departs at 11:59 PM
The cheapest flight ticket from Madrid to Santiago according to data for the last 48 hours costs $378
Often the best time to buy tickets from Madrid to Santiago is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Madrid to Santiago can be found flying in these months: April, May, March.
The fastest flights from Madrid to Santiago start from 12 hours 20 minutes in the air.
The following airlines operate direct flights on the route Madrid — Santiago: Iberia, LATAM Chile
The minimum one-way ticket price from Madrid to Santiago is $378 (April 2026), while the maximum is $610 (June 2026). On average, a ticket costs $473–$997.