Unable to find information about the schedule of direct flights from
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Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santiago to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A non-stop flight is the most convenient and comfortable way to fly from Santiago to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santiago to Panama City:
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Answers to questions about the route that travelers are most interested in.
We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
Unable to find information about the schedule of direct flights from
Santiago — Panama City
02/02/2026
Departure
Direct flight
CM396
starting at $1,090
Santiago — Panama City
02/03/2026
Departure
Direct flight
CM475
starting at $1,092
Santiago — Panama City
02/04/2026
Departure
Direct flight
CM276
starting at $1,182
Santiago — Panama City
02/05/2026
Departure
Direct flight
CM174
starting at $1,008
Santiago — Panama City
12/29/2026
Departure
Direct flight
CM174
starting at $1,120
The route Santiago — Panama City is served by several airlines: Copa Airlines, Avianca, and B&H Airlines. This gives passengers more freedom in choosing flights. You can consider not only the price but also schedules, baggage policies, and onboard service. Our service compares all offers so you can find tickets from $279 and choose the most convenient option. Thanks to airline competition, you may also find promotional fares or special offers, helping you save even more. Plan your trip in advance and choose the best flights without overpaying.
The cheapest one-way flight from Santiago to Panama City departs on 12/29/2026, is operated by Avianca and costs $279
The cheapest roundtrip flight from Santiago to Panama City departs on 05/05/2026, is operated by Avianca and costs $493
Fastest flight from Santiago to Panama City takes 12h 51m
There are direct flights on this route 4 days a week: Mo, Tu, We, and Th
The distance between Santiago and Panama City is 4810km (2982 miles). There are 12 direct flights from Santiago to Panama City. The time difference between Santiago and Panama City is 1h. Flights from Santiago begin at 5:20 AM. The latest flight from Santiago departs at 3:34 AM
We couldn't find any special offers for flights from Santiago to Panama City
The cheapest flight ticket from Santiago to Panama City according to data for the last 48 hours costs $279
Often the best time to buy tickets from Santiago to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santiago to Panama City can be found flying in these months: December, February.
The fastest flights from Santiago to Panama City start from 12 hours 51 minutes in the air.
The following airlines operate direct flights on the route Santiago — Panama City: Copa Airlines
The minimum one-way ticket price from Santiago to Panama City is $279 (December 2026), while the maximum is $473 (February 2026). On average, a ticket costs $376–$473.
