Starting at $593
Starting at $219
Starting at $233
Starting at $296
Helping travelers to find the best flight offers
Flaut.Travel was designed and developed by a team dedicated to making the process of searching, comparing and booking airline tickets as easy and convenient as possible. Our service helps travelers to find and buy the cheapest flights from Santo Domingo to Panama City. We have connected more than 40 airlines and airline ticketing agencies to help you find the most suitable and affordable flight option.
A direct flight is the most convenient and comfortable way to fly from Santo Domingo to Panama City, despite the fact that sometimes flights with transfers can cost significantly less.
A direct flight is the easiest way to get to your destination. The following airlines operate non-stop flights from Santo Domingo to Panama City:
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We keep tight track on airlines' pre-holidays sales and other special offers occurences all the time to let you save maximum amount of funds while traveling to your family or just going out on vacation.
The Santo Domingo — Panama City route is served by a wide range of airlines: 4 in total, including Copa Airlines, Asian Air, Avianca, and Frontier Airlines. Competition among carriers gives passengers the opportunity to find tickets at attractive fares — with prices starting from $219. Our service helps compare all available offers within seconds and choose the most convenient option. You can filter flights by price, departure time, or baggage rules to make your trip as comfortable as possible. With so many airlines, there’s always a chance to catch special promotions and save.
Starting at $593
Starting at $219
Starting at $233
Starting at $296
Santo Domingo — Panama City
12/12/2025
Departure
Direct flight
CM267
Starting at $971
Santo Domingo — Panama City
01/03/2026
Departure
Direct flight
CM129
Starting at $685
Santo Domingo — Panama City
02/23/2026
Departure
Direct flight
CM464
Starting at $642
Santo Domingo — Panama City
02/25/2026
Departure
Direct flight
CM299
Starting at $593
Santo Domingo — Panama City
10/20/2026
Departure
Direct flight
CM108
Starting at $601
Unable to find information about the schedule of direct flights from
The cheapest one-way flight from Santo Domingo to Panama City departs on 02/25/2026, is operated by Asian Air and costs $219
The cheapest roundtrip flight from Santo Domingo to Panama City departs on 12/16/2025, is operated by Avianca and costs $539
Fastest flight from Santo Domingo to Panama City takes 8h 48m
There are no direct flights on this route.
The distance between Santo Domingo and Panama City is 1474km (914 miles). There are 34 direct flights from Santo Domingo to Panama City. The time difference between Santo Domingo and Panama City is 1h. Flights from Santo Domingo begin at 6:00 AM. The latest flight from Santo Domingo departs at 6:39 PM
We couldn't find any special offers for flights from Santo Domingo to Panama City
The cheapest flight ticket from Santo Domingo to Panama City according to data for the last 48 hours costs $219
Often the best time to buy tickets from Santo Domingo to Panama City is 2 months before departure.
Based on statistics over the past years, the lowest prices for flights from Santo Domingo to Panama City can be found flying in these months: February, January.
The fastest flights from Santo Domingo to Panama City start from 8 hours 48 minutes in the air.
The following airlines operate direct flights on the route Santo Domingo — Panama City: Copa Airlines
The minimum one-way ticket price from Santo Domingo to Panama City is $219 (February 2026), while the maximum is $414 (January 2026). On average, a ticket costs $316–$414.